Top 5 Facts You Should Know About Ketamine Infusion for Depression

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Ketamine infusion therapy is a safe, rapid, and easy procedure that can help you if you are depressed. Ketamine was initially used as an anesthetic but has recently gained popularity in managing some major forms of depression. The Park Slope Ketamine infusion treatment specialists can help design a treatment plan for you based on the symptoms and severity of your depression. The treatment can be done on an outpatient basis with sessions of about an hour, including recovery time.  Explore more about the treatment herein.

Why Ketamine for Depression

Ketamine has become exciting recently for treating depression. If you can respond to ketamine, it can rapidly minimize any life-threatening thoughts and acts and improve other serious symptoms of depression. Ketamine can also help you manage depression combined with anxiety. While other treatments like talk therapies, transcranial magnetic stimulation, antidepressant medicines, and electroconvulsive therapy can effectively manage depression, they may take weeks or even months. But you can notice improvements with every ketamine infusion you get.

Different Types of Ketamine

Major depression can be managed through two main types of ketamine. Racemic ketamine is the most popular ketamine given as an infusion. It is also referred to as intravenous (IV) ketamine and is a mixture of two molecules: the R and S ketamine. Esketamine, which was FDA approved recently, is mainly given as a nasal spray and uses only the S molecule.

So far, racemic and esketamine are the types of ketamine based on most research. They interact differently with brain receptors, and it is not yet known which is more effective or has fewer side effects.

How Ketamine Work

Although it is unknown how ketamine works, it is believed to exert an antidepressant effect through a new mechanism. It is a good option when you have tried other treatment options for depression, and they have not worked. The NMDA receptors in the brain are likely targeted by ketamine which binds the receptors to increase the number of glutamate neurotransmitters. This activates connections in the AMPA receptor, another receptor in the brain, leading to the release of molecules that help neurons communicate effectively with each other.

This process affects mood, cognition, and thought patterns.

Ketamine can also influence depression in other ways like reducing inflammation signals which are linked to mood disorders.

Possible Side Effects of Ketamine

Like any other drug, ketamine can cause some effects on your overall well being. But when you are severely depressed or suicidal, possible benefits will outweigh the risks. Generally, you may experience nausea and vomiting, high blood pressure, perceptual disturbances, and dissociation. But long-term use of ketamine infusion may come with additional side effects. However, deeper research is needed to understand better the effects associated with ketamine.

Additional Information

Note that ketamine is addictive like opioids and should be taken cautiously. Also, note that subsequent ketamine infusion sessions can help prolong the positive effects of the treatment. Some people can respond to ketamine within one to three infusions, and if one fails to respond, it is advisable to try other treatments for depression. Remember to limit your subsequent sessions as they may prolong side effects rather than offer relief.

Learn if ketamine infusion therapy can help with your depression by contacting David Salvage, M.D., FAPM today. No matter how you may have unsuccessfully tried antidepressants and other treatments, this could be your chance to get some relief from your condition. 

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